Publication « Chest tcpO2 changes during constant-load treadmill walking tests in patients with claudication. »

N. Ouedraogo1,2, M. Feuilloy3, G. Mahe2, G. Leftheriotis1,2, J.-L. Saumet4 et P. Abraham1,2,5.

Physiological Measurement, 32(2):181-194, février 2011.

Lien :


Changes in chest transcutaneous-pO2 at rest (ΔtcpO2) mimic absolute changes in arterial-pO2 during moderate exercise, although the absolute starting values may dramatically differ. We retrospectively studied 485 patients (group 1), prospectively studied 292 new patients (group 2) and estimated the intra-test and the test–retest reproducibility of ΔtcpO2 during constant-load treadmill tests: 3.2 km h−1, 10% grade, using the cross correlation technique. Patients were classified into groups according to their best fit to nine pre-defined mathematic models. Respectively, 71% and 76% of patients of groups 1 and 2 fitted with a model showing a ΔtcpO2 increase during and a decrease following exercise. Another 18% and 12% of the patients of groups 1 and 2 respectively fitted with a model that showed an abrupt decrease at exercise onset, a slow increase during walking and an overshoot in the recovery period, referred here as a walking-induced transcutaneous hack (WITH) profile. The mean rmax value for the cross-correlation analysis was 0.919 ± 0.091 and 0.800 ± 0.129 for intra-test and test–retest reproducibility. Most profiles show the expected ΔtcpO2 exercise-induced increase. Future studies are needed to confirm and explain the WITH profiles that we found, and screen for potential-associated diseases.

1 Laboratory of Physiology, CNRS, UMR6214, Angers, F-49045 France, Inserm, U771, Angers, F-49045 France, Medical School, University of Angers, Angers, F-49045, France

2 Laboratory for Vascular Investigations, University Hospital, Angers Cedex 01, F-49033, France

3 GSII, Superior School for Electronics, ESEO, Angers, France

4 FRE CNRS 3075, Lyon 1, France

5 Author to whom any correspondence should be addressed